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Publications 2019-2020

Health category

Publication Reference

DOI

Metabolic & endocrine

Shepherd M. Improving patient care in monogenic diabetes through research and education. Practical Diabetes. May 2019; 36 (3):97-101

https://doi.org/10.1002/pdi.2223

Metabolic & endocrine

Oram RA, Redondo MJ. New insights on the genetics of type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. Aug 2019;26(4):181–187

10.1097/MED.0000000000000489

Metabolic & endocrine

Thomas NJ, Lynam AL, Hill AV, Weedon MHn, Shields BM, Oram RA, McDonald TJ, Hattersley AT & Jones AG. Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes. Diabetologia. Apr 2019;62:1167–1172

https://doi.org/10.1007/s00125-019-4863-8

Metabolic & endocrine

Marren SM, Hammersley S2, McDonald TJ1,2,3, Shields BM1,2, Knight BA2, Hill A2, Bolt R2, Tree TI4,5, Roep BO6,7, Hattersley AT1,2, Jones AG1,2, Oram RA1,2; TIGI consortium. Persistent C-peptide is associated with reduced hypoglycaemia but not HbA1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice? Diabet Med. 2019 Sep;36(9):1092-109

https://doi.org/10.1111/dme.13960

Cancer & neoplasms

Pranjol, M.Z.I., Zinovkin, D.A., Maskell, A.R.T. et al. Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma. J Transl Med. July 2019; 17(216):14-15

https://doi.org/10.1186/s12967-019-1963-7

Respiratory

Stucky Hunter E, Richardson MD, Denning DW. Evaluation of LDBio Aspergillus ICT lateral flow assay for IgG and IgM antibody detection in chronic pulmonary aspergillosis. J Clin Microbiol. 2019;57(9):1-12

https://doi.org/10.1128/JCM.00538-19

Cancer & neoplasms

Munkley J, Ling L, Krishnan SRG, Hysenaj G, Scott E, Dalgliesh C, Oo HZ, Maia TM, Cheung K, Ehrmann I, Livermore KE, Zielinska H, Thompson O, Knight B, McCullagh P, McGrath J, Crundwell M, Harries LW, Daugaard M, Cockell S, Barbosa-Morais NL, Oltean S, Elliott DJ. Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer. Elife. Sept 2019;8:e47678

https://doi.org/10.7554/eLife.47678

Cardiovascular/Paediatrics

Farr C, Middlebrooke AR, Armstrong N, Barker AR, Fulford J, Mawson DM, McManus AM. Objectively Measured Aerobic Fitness is Not Related to Vascular Health Outcomes and Cardiovascular Disease Risk In 9-10 Year Old Children. J Sports Sci Med. 2019 Aug 1;18(3):513-522

http://hdl.handle.net/10871/38550

Musculoskeletal

Heales CJ, Summers IR, Fulford J, Knapp KM, Winlove CP. Investigation of changes in bone density and chemical composition associated with bone marrow oedema-type appearances in magnetic resonance images of the equine forelimb. BMC Musculoskelet Disord. 2019 Jul 15;20(1):330

https://doi.org/10.1186/s12891-019-2693-y

Musculoskeletal

Morgan PT, Bailey SJ, Banks RA, Fulford J, Vanhatalo A, Jones AM. Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion. Am J Physiol Regul Integr Comp Physiol. 2019 Aug 1;317(2):R346-R354

https://doi.org/10.1152/ajpregu.00084.2019

Cardiovascular

Aizawa K, Ramalli A, Sbragi S, Tortoli P, Casanova F, Morizzo C, Thorn CE, Shore AC, Gates PE, Palombo C. Arterial wall shear rate response to reactive hyperaemia is markedly different between young and older humans. J Physiol. 2019;597 (16):4151–4163

https://doi.org/10.1113/JP278310

Metabolic & endocrine

Dennis JM, Henley WE, McGovern AP, Farmer AJ, Sattar N, Holman RR, Pearson ER, Hattersley AT, Shields BM, Jones AG; MASTERMIND consortium. Time trends in prescribing of type 2 diabetes drugs, glycaemic response and risk factors: A retrospective analysis of primary care data, 2010-2017. Diabetes Obes Metab. 2019 Jul;21(7):1576-1584

https://doi.org/10.1111/dom.13687

Metabolic & endocrine

Dennis JM, Shields BM, Henley WE, Jones AG, Hattersley AT. Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data. Lancet Diabetes Endocrinol. 2019 Jun;7(6):442-451

https://doi.org/10.1016/S2213-8587(19)30087-7

Metabolic & endocrine

McGovern AP, Dennis JM, Shields BM, Hattersley AT, Pearson ER, Jones AG; MASTERMIND Consortium. What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study. BMC Med. 2019;17:79

https://doi.org/10.1186/s12916-019-1307-8

Metabolic & endocrine

Lynam A, McDonald TJ, Hill AV, Dennis JM, Oram RA, Pearson ER, Weedon MN, Hattersley AT, Owen KR, Shields BM, Jones AG. Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18 to 50. BMJ Open. 2019;9(9):e031586

http://dx.doi.org/10.1136/bmjopen-2019-031586

Metabolic & endocrine

Wilman HR, Parisinos CA, Atabaki-Pasdar N, Kelly M, Thomas EL, Neubauer S; IMI DIRECT Consortium, Mahajan A, Hingorani AD, Patel RS, Hemingway H, Franks PW, Bell JD, Banerjee R, Yaghootkar H. Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration. Journal of Hepatology. 2019 Sep;71(3):594-602

https://doi.org/10.1016/j.jhep.2019.05.032

Metabolic & endocrine

Dawed AY, Zhou K, van Leeuwen N, Mahajan A, Robertson N, Koivula R, Elders PJM, Rauh SP, Jones AG, Holl RW, Stingl JC, Franks PW, McCarthy MI, ‘t Hart L, Pearson ER; IMI DIRECT Consortium. Variation in the Plasma Membrane Monoamine Transporter (PMAT, Encoded in SLC29A4) and Organic Cation Transporter 1 (OCT1, Encoded in SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study. Diabetes Care. 2019 Jun;42(6):1027-1033

https://doi.org/10.2337/dc18-2182

Musculoskeletal

Kilroe SP, Fulford J, Holwerda AM, Jackman SR, Lee BP, Gijsen AP, van Loon LJC, Wall BT. Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates. Am J Physiol Endocrinol Metab. 2019; [Epub ahead of print] PMID: Am J Physiol Endocrinol Metab 318: E117–E130, 2020

https://doi.org/10.1152/ajpendo.00360.2019

Musculoskeletal

Kilroe SP, Fulford J, Jackman SR, van Loon LJC, Wall BT. Temporal Muscle-Specific Disuse Atrophy during One Week of Leg Immobilization. Med Sci Sports Exerc. 2019 Nov 1. [Epub ahead of print] PMID:31688656

https://doi.org/10.1249/mss.0000000000002200

Metabolic & endocrine

Rodgers LR, Dennis JM, Shields BM, Mounce L, Fisher I, Hattersley AT, Henley WE for the MASTERMIND Consortium. Prior event rate ratio adjustment produced estimates consistent with randomized trial: a diabetes case study. J Clin Epidemiol. 2020 Mar 17;122:78-86

https://doi.org/10.1016/j.jclinepi.2020.03.007

Metabolic & endocrine

Bowman P, McDonald TJ, Knight BA, Flanagan SE, Leveridge M, Spaull SR, Shields BM, Hammersley S, Shepherd MH, Andrews RC, Patel KA, Hattersley AT. Patterns of post-meal insulin secretion in individuals with sulfonylurea-treated KCNJ11 neonatal diabetes show predominance of non-KATP-channel pathways. BMJ Open Diabetes Research and Care. 2019;7:e000721

http://dx.doi.org/10.1136/bmjdrc-2019-000721

Cardiovascular

Deane CS, Phillips BE, Smith K, Steele AM, Libretto T, Statton SA, Atherton P J & Etheridge T. Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials. BMC Research Notes. 2020; 13 (174):1-7

https://doi.org/10.1186/s13104-020-05017-1

Metabolic & endocrine

Casanova F, Gooding KM, Shore AC, Adingupu DD, Mawson D, Ball C et al. Weight change and sulfonylurea therapy are related to 3 year change in microvascular function in people with type 2 diabetes. Diabetologia. 2020;63(6):1268-1278

https://doi.org/10.1007/s00125-020-05125-4

Oral & gastrointestinal

Sazonovs A, Kennedy N, Moutsianas L, Heap G, Rice D, Reppell M, Bewshea C, Chanchlani N, Walker G, Perry M, McDonald T, Lees C, Cummings JRF, Parkes M, Mansfield J, Barrett J, McGovern D, Goodhand J, Anderson C, Ahmad T. HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn’s Disease. Gastroenterology. Jan 2019;158(1):189-199

https://doi.org/10.1053/j.gastro.2019.09.041

Metabolic & endocrine

Peters JL, Anderson R, Shields B, King S, Hudson M, Shepherd M, McDonald TJ, Pearson E, Hattersley A, Hyde C. Strategies to identify individuals with monogenic diabetes: results of an economic evaluation. BMJ Open. 2020;10:e034716

http://dx.doi.org/10.1136/bmjopen-2019-034716

Metabolic & endocrine

Carlsson A, Shepherd M, Ellard S, Weedon M, Lernmark Å, Forsander G, Colclough K, Brahimi Q, Valtonen-Andre C, Ivarsson SA, Elding Larsson H, Samuelsson U, Örtqvist E, Groop L, Ludvigsson J, Marcus C, Hattersley AT. Absence of islet autoantibodies and modestly raised glucose values at diabetes diagnosis are critical features of MODY: Lessons from a 5-year paediatric Swedish national cohort study. Diabetes Care. 2020 Jan;43(1):82-89

https://doi.org/10.2337/dc19-0747

Cardiovascular

Williams J, Gilchrist M, Strain D, Fraser D, Shore A. The systemic microcirculation in dialysis populations. Microcirculation. 2020;00:1-11

https://doi.org/10.1111/micc.12613

Mental health

Zeman A, Milton F, Sala SD, Dewar M, Frayling T, Gaddum J, Hattersley A, Heuerman-Williamson B, Jones K, MacKisack M, Winlove C. Phantasia- the psychological significance of lifelong visual imagery vividness extremes. Cortex. 2020, in press

https://doi.org/10.1016/j.cortex.2020.04.003

Metabolic & endocrine

Johnson MB, De Franco E, Greeley SAW, Letourneau LR, Gillespie KM; International DS-PNDM Consortium, Wakeling MN, Ellard S, Flanagan SE, Patel KA, Hattersley AT. Trisomy 21 Is a Cause of Permanent Neonatal Diabetes That Is Autoimmune but Not HLA Associated. Diabetes. 2019 Jul;68(7):1528-1535

https://doi.org/10.2337/db19-0045

Cardiovascular

Farr C, Middlebrooke AR, Armstrong N, Barker AR, Fulford J, Mawson DM, McManus AM. Objectively Measured Aerobic Fitness is Not Related to Vascular Health Outcomes and Cardiovascular Disease Risk In 9-10 Year Old Children. J Sports Sci Med. 2019 Aug 1;18(3

https://doi.org/10.1016/j.ajhg.2019.03.018

Metabolic & endocrine

Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J et al. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet. 2019 May;51(5):804-814

https://doi.org/10.1038/s41588-019-0403-1

Metabolic & endocrine

Dennis JM, Shields BM, Henley WE, Jones AG, Hattersley AT. Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data. Lancet Diabetes Endocrinol. 2019 Jun;7(6):442-451

http://dx.doi.org/10.1016/ S2213-8587(19)30087-7

Metabolic & endocrine

Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, De Masi F, Groves CJ, Kokkola T, Mahajan A, Perry MH, Rauh SP, Ridderstråle M, Teare HJA, Thomas EL, Tura A, Vestergaard H, White T, Adamski J, Bell JD, Beulens JW, Brunak S, Dermitzakis ET, Froguel P, Frost G, Gupta R, Hansen T, Hattersley A, Jablonka B, Kaye J, Laakso M, McDonald TJ, Pedersen O, Schwenk JM, Pavo I, Mari A, McCarthy MI, Ruetten H, Walker M, Pearson E, Franks PW; IMI DIRECT Consortium. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium. Diabetologia. 2019 Sep;62(9):1601-1615

https://doi.org/10.1007/s00125-019-4906-1

Metabolic & endocrine

Thompson WD, Tyrrell J, Borges MC, Beaumont RN, Knight BA, Wood AR, Ring SM, Hattersley AT, Freathy RM, Lawlor DA. Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis. PLoS Med. 2019 Jun 18;16(6):e1002828

https://doi.org/10.1371/journal. pmed.1002828

Metabolic & endocrine

Shields BM, Hattersley AT, Farmer AJ. Identifying routine clinical predictors of non-adherence to second-line therapies in type 2 diabetes: A retrospective cohort analysis in a large primary care database. Diabetes Obes Metab. 2020 Jan;22(1):59-65

https://doi.org/10.1111/dom.13865

Metabolic & endocrine

Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, Wood AR. A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Hum Mol Genet. 2019 Dec 15;28(24):4197-4207

https://doi.org/10.1093/hmg/ddz243

Metabolic & endocrine

Ellard S, Colclough K, Patel KA, Hattersley AT. Prediction algorithms: pitfalls in interpreting genetic variants of autosomal dominant monogenic diabetes. J Clin Invest. 2020 Jan 2;130(1):14-16

https://doi.org/10.1172/JCI133516

Metabolic & endocrine

De Franco E, Caswell R, Johnson MB, Wakeling MN, Zung A, Dũng VC, Bích Ngọc CT, Goonetilleke R, Vivanco Jury M, El-Khateeb M, Ellard S, Flanagan SE, Ron D, Hattersley AT. De Novo Mutations in EIF2B1 Affecting eIF2 Signaling Cause Neonatal/Early-Onset Diabetes and Transient Hepatic Dysfunction. Diabetes. 2020 Mar;69(3):477-483

https://doi.org/10.2337/db19-1029

Metabolic & endocrine

Casanova F, Wood AR, Yaghootkar H, Beaumont RN, Jones SE, Gooding KM, Aizawa K, Strain WD, Hattersley AT, Khan F, Shore AC, Frayling TM, Tyrrell J. A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function. Diabetes. 2020 May;69(5):1072-1082

https://doi.org/10.2337/db19-0862

Metabolic & endocrine

Koivula RW, Atabaki-Pasdar N, Giordano GN, White T, Adamski J, Bell JD, Beulens J, Brage S, Brunak S, De Masi F, Dermitzakis ET, Forgie IM, Frost G, Hansen T, Hansen TH, Hattersley A, Kokkola T, Kurbasic A, Laakso M, Mari A, McDonald TJ, Pedersen O, Rutters F, Schwenk JM, Teare HJA, Thomas EL, Vinuela A, Mahajan A, McCarthy MI, Ruetten H, Walker M, Pearson E, Pavo I, Franks PW, IMI DIRECT Consortium. The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study. Diabetologia. 2020 Apr;63(4):744-756

https://doi.org/10.1007/s00125-019-05083-6

Metabolic & endocrine

Leete P, Oram RA, McDonald TJ, Shields BM, Ziller C; TIGI study team, Hattersley AT, Richardson SJ, Morgan NG. 20. Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis. Diabetologia. 2020 Mar 15. [Epub ahead of print]

https://doi.org/10.1007/s00125-020-05115-6

renal

Williams JK, Smallwood MJ, Benjamin N, D’Souza RJ, Shore AC, Winyard PG, Gilchrist M. Renal nitrate clearance in chronic kidney disease. Nitric Oxide. Jan 2020;97:16-19

https://doi.org/10.1016/j.niox.2020.01.011

Cardiovascular

Jordan AN, Anning C, Wilkes L, Ball C, Pamphilon N, Clark CE, Bellenger NG, Shore AC, Sharp ASP. Rapid treatment of moderate to severe hypertension using a novel protocol in a single-centre, before and after interventional study. Journal of Human Hypertension Feb 2020 34(2):165-175

https://doi.org/10.1038/s41371-019-0272-1

Surgery

To C, Rees-Lee JE, Gush RJ, Gooding KM, Cawrse NH, Shore AC, Wilson ADH. Reply: Intraoperative Tissue Perfusion Measurement by Laser Speckle Imaging: A Potential Aid for Reducing Postoperative Complications in Free Flap Breast Reconstruction. Plast Reconstr Surg Nov 2019 144(5):935e-936e

doi: 10.1097/PRS.0000000000006125

Metabolic & endocrine

Chapman DP, Gooding KM, McDonald TJ, Shore AC. Stability of urinary albumin and creatinine after 12 months storage at −20 °C and −80 °C. Practical Laboratory Medicine. May 2019;15:e00120

https://doi.org/10.1016/j.plabm.2019.e00120

Musculoskeletal

Tomlinson OW, Barker AR, Fulford J, Wilson P, Oades PJ, Williams CA. Quantification of thigh muscle volume in children and adolescents using magnetic resonance imaging. Eur J Sport Sci. 2020 Jan 12:1-10

https://doi.org/10.1080/17461391.2019.1707292

Musculoskeletal

Campbell M, Varley-Campbell J, Fulford J, Taylor B, Mileva KN, Bowtell JL. Effect of Immobilisation on Neuromuscular Function In Vivo in Humans: A Systematic Review. Sports Med. 2019 Jun;49(6):931-950

https://doi.org/10.1007/s40279-019-01088-8

Neurology

Reichmann H, Lees A, Rocha J, Magalhães D, Soares-da-Silva P and the OPTIPARK investigators. Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study. Transl Neurodegener. March 2020;9 (9):1-9

https://doi.org/10.1186/s40035-020-00187-1

Metabolic & endocrine

Aung MM, Slade K, Freeman LAR, Kos K, Whatmore JL, Shore AC, Gooding K. Locally delivered GLP-1 analogues liraglutide and exenatide enhance microvascular perfusion in individuals with and without type 2 diabetes. Diabetologia. 2019;62: 1701–1711

https://doi.org/10.1007/s00125-019-4918-x

Inflammatory & immune system

Lear, R, O’Leary M, O’Brien Andersen, L, Holt, C.C, Stensvold, C.R, van der Giezen, M, Bowtell, J.L. Tart Cherry Concentrate Does Not Alter the Gut Microbiome, Glycaemic Control or Systemic Inflammation in a Middle-Aged Population. Nutrients 2019, 11, 1063

https://doi.org/10.3390/nu11051063

Metabolic & endocrine

Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ et al. Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes. Diabetes Care. Jan 2020, 43 (1) 5-12

https://doi.org/10.2337/dc19-0880

Blood

Vara D, Cifuentes-Pagano E, Pagano PJ, Pula G. A novel combinatorial technique for simultaneous quantification of oxygen radicals and aggregation reveals unexpected redox patterns in the activation of platelets by different physiopathological stimuli. Haematol. 2019;104(9):1879-1891

https://doi.org/10.3324/haematol.2018.208819

Mental health

Brooker H, Wesnes KA, Ballard C, Hampshire A, Aarsland D, Khan Z, Stenton R, McCambridge L, Corbett A. An online investigation of the relationship between the frequency of word puzzle use and cognitive function in a large sample of older adults. Int J Geriatr Psychiatry. 2019;34(7):921-931

https://doi.org/10.1002/gps.5033

Mental health

Brooker H, Wesnes KA, Ballard C, Hampshire A, Aarsland D, Khan Z, Stenton R, Megalogeni M, Corbett A. The relationship between the frequency of number‐puzzle use and baseline cognitive function in a large online sample of adults aged 50 and over. Int J Geriatr Psychiatry. 2019 July;34:932–940

https://doi.org/10.1002/gps.5085

Mental health

Creese B, Brooker H, Ismail Z, Wesnes KA, Hampshire A, Khan Z, Megalogeni M, Corbett A, Aarsland D, Ballard C. Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. Am J Geriatr Psychiatry. 2019 Aug;27(8):823-834

https://doi.org/10.1016/j.jagp.2019.01.215

Oral & gastrointestinal

Kennedy NA, Heap GA, Green HD, Hamilton B, Bewshea C, Walker GJ et al. Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn’s disease: a prospective, multicentre, cohort study. Lancet Gastroenterol Hepatol. 2019;4(5):341-353

https://doi.org/10.1016/S2468-1253(19)30012-3

Metabolic & endocrine

Ishibashi F, Tavakoli M. Thinning of Macular Neuroretinal Layers Contributes to Sleep Disorder in Patients With Type 2 Diabetes Without Clinical Evidences of Neuropathy and Retinopathy. Front Endocrinol (Lausanne). 2020;11:69

https://doi.org/10.3389/fendo.2020.00069

Mental health

Lewis EJH, Lovblom LE, Ferdousi M, Halpern EM, Jeziorska M, Pacaud D et al. Rapid Corneal Nerve Fiber Loss: A Marker of Diabetic Neuropathy Onset and Progression. Diabetes Care. 2020;43(8):1829-1835

https://doi.org/10.2337/dc19-0951

Metabolic & endocrine

Ishibashi F, Taniguchi M, Kosaka A, Uetake H, Tavakoli M. Improvement in Neuropathy Outcomes With Normalizing HbA1c in Patients With Type 2 Diabetes. Diabetes Care. 2019;42(1):110-118

https://doi.org/10.2337/dc18-1560

Mental health

Stewart GR, Corbett A, Ballard C, Creese B, Aarsland D, Hampshire A,

Charlton RA & Happé F. The Mental and Physical Health of Older Adults With a Genetic Predisposition for Autism. Autism Research. 2020; 13: 641–654

https://doi.org/10.1002/aur.2277

Cardiovascular

Farr C, Middlebrooke AR, Armstrong N, Barker AR, Fulford J, Mawson DM, McManus AM. Objectively Measured Aerobic Fitness is Not Related to Vascular Health Outcomes and Cardiovascular Disease Risk In 9-10 Year Old Children. J Sports Sci Med. 2019 Aug 1;18(3

https://doi.org/10.1111/dme.14058

Inflammatory & immune system

Liu X, Helenius D, Skotte L, Beaumont RN, Wielscher M, Geller F, Juodakis J et al. Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration. Nat Commun. 2019 Sept; 10:3927

https://doi.org/10.1038/s41467-019-11881-8

Metabolic & endocrine

Oram RA, Sims EK & Evans-Molina C. Beta cells in type 1 diabetes: mass and function; sleeping or dead?. Diabetologia. 2019;62:567–57

https://doi.org/10.1007/s00125-019-4822-4

Cardiovascular

Banerjee A, Benedetto V, Gichuru P, et al. Adherence and persistence to direct oral anticoagulants in atrial fibrillation: a population-based study. Heart. 2020;106:119-126

http://dx.doi.org/10.1136/heartjnl-2019-315307

Metabolic & endocrine

Novak A, Bowman B, Kraljevic I, Tripolski M, Houghton JAL, De Franco E, Shepherd MH, Skrabic V, Patel KA. Transient Neonatal Diabetes: An Etiologic Clue for the Adult Diabetologist. Can J Diabetes. 2020 Mar; 44(2): 128–130

https://doi.org/10.1016/j.jcjd.2019.05.002

Metabolic & endocrine

Strain WD, McEwan P, Howitt H, Meadowcroft S. Retrospective Database Analysis Evaluating the Clinical Outcomes of Changing Treatment of People with Type 2 Diabetes Mellitus (T2DM) from Other DPP-4 Inhibitor Therapy to Alogliptin in a Primary Care Setting. Diabetes Ther. 2019 July;10:1499–1507

https://doi.org/10.1007/s13300-019-0662-y

Metabolic & endocrine

De Franco E, Watson RA, Weninger WJ, Wong CC, Flanagan SE, Caswell R, Green A, Tudor C, Lelliott CJ, Geyer SH, Maurer-Gesek B, Reissig LF, Lango Allen H, Caliebe A, Siebert R, Holterhus PM, Deeb A, Prin F, Hilbrands R, Heimberg H, Ellard S, Hattersley AT, Barroso I. A Specific CNOT1 Mutation Results in a Novel Syndrome of Pancreatic Agenesis and Holoprosencephaly through Impaired Pancreatic and Neurological Development. Am J Hum Genet. 2019 May 2; 104(5): 985–989

https://doi.org/10.1016/j.ajhg.2019.03.018

Mental health

Grasso AC, Olthof MR, van Dooren C, Roca M, Gili M, Visser M, Cabout M, Bot M, Penninx BWJH, van Grootheest G, Kohls E, Hegerl U, Owens M, Watkins E, Brouwer IA & the MooDFOOD Prevention Trial Investigators. Effect of food-related behavioral activation therapy on food intake and the environmental impact of the diet: results from the MooDFOOD prevention trial. Eur J Nutr. 2019 Oct;59:2579–2591

https://doi.org/10.1007/s00394-019-02106-1

Mental health

Baldofski S, Mauche N, Dogan-Sander E, Bot M, Brouwer IA, Paans NPG, Cabout M, Gili M, van Grootheest G, Hegerl U, Owens M, Roca M, Visser M, Watkins E, Penninx BW JH, Kohls E. Depressive Symptom Clusters in Relation to Body Weight Status: Results From Two Large European Multicenter Studies. Frontiers in Psychiatry. 2019 Nov;10:858

https://doi.org/10.3389/fpsyt.2019.00858

Metabolic & endocrine

Bain SC, Bakhai A, Evans M, Green A, Menown I, Strain WD. Pharmacological treatment for Type 2 diabetes integrating findings from cardiovascular outcome trials: an expert consensus in the UK. Diabet Med. 2019 Sep; 36(9): 1063–1071

https://doi.org/10.1111/dme.14058

Cancer & neoplasms

Nallala J, Jeynes C, Saunders S, Smart N, Lloyd G, Riley L, Salmon D, Stone N. Characterization of colorectal mucus using infrared spectroscopy: a potential target for bowel cancer screening and diagnosis. Lab Invest. 2020;100:1102–1110

https://doi.org/10.1038/s41374-020-0418-3

Inflammatory & immune system

Lennox B, Yeeles K, Jones PB, Jones PB, Zandi M, Joyce E, Yu L-M, Tomei G, Pollard R, Vincent S-A, Shimazaki M, Cairns I, Dowling F, Kabir T, Barnes TRE, Hughes AL, Hosseini AA, Harrower T, Buckley C, Coles A. Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2). Trials.2019;20:331

https://doi.org/10.1186/s13063-019-3336-1

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